![]() In contrast, the balance of synaptic excitation and inhibition differs in a layer-specific pattern from one to four postnatal weeks of age. Our data demonstrate similar maturation profiles of dendritic morphology and intrinsic properties of pyramidal neurons in both deep and superficial layers. Here, we provide a detailed morphological and functional characterisation of pyramidal neurons in mouse mPFC during the first postnatal month, corresponding to known critical periods for synapse and neuron formation in mouse sensory neocortex. ![]() While the differences between principal cells across layers have been extensively studied, it is not known how the developmental profiles of neurons in different layers compare. ![]() Each layer is populated by distinct subtypes of principal cells that are born at different times during development. ![]() Mammalian neocortex is a highly layered structure. ![]()
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